Product Datasheet  
ARNT Antibody  
Catalog Number: 33731  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P27540
    NCBI Gene ID: 405
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human ARNT.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Aryl hydrocarbon receptor nuclear translocator; Dioxin receptor; nuclear translocator; HIF-1 beta; Hypoxia-inducible factor 1 beta
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total ARNT protein.
  • Applications：  
  • WB
  • Background：  
  • Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.

    Hoffman E.C., Science 252:954-958(1991).
    Wang G.L., Proc. Natl. Acad. Sci. U.S.A. 92:5510-5514(1995).
    Nguyen T.A., Arch. Biochem. Biophys. 367:250-257(1999).



 
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