Product Datasheet  
MARK3 Antibody  
Catalog Number: 33730  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P27448
    NCBI Gene ID: 4140
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from N-terminal of human MARK3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • C-TAK1; Cdc25C- associated protein kinase 1; EC 2.7.11.1; MAP/microtubule affinity-regulating kinase 3; Protein kinase STK10
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MARK3 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.

    Peng C.Y., Cell Growth Differ. 9:197-208(1998).
    Sun T.-Q., Nat. Cell Biol. 3:628-636(2001).
    Wissing J., Mol. Cell. Proteomics 6:537-547(2007)



 
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