Product Datasheet  
MBD3 Antibody  
Catalog Number: 33640  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O95983
    NCBI Gene ID: 53615
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human MBD3.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3; MBD3;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MBD3 protein.
  • Applications：  
  • WB
  • Background：  
  • Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (). Recruits histone deacetylases and DNA methyltransferases.

    Hendrich B., Mol. Cell. Biol. 18:6538-6547(1998).
    Grimwood J., Nature 428:529-535(2004).
    Tatematsu K., Genes Cells 5:677-688(2000).



 
© Signalway Biotechnology All Rights Reserved.