Product Datasheet  
AKAP10 Antibody  
Catalog Number: 33587  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O43572
    NCBI Gene ID: 11216
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human AKAP10.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • A kinase anchor protein 10; mitochondrial [Precursor]; Protein kinase A-anchoring protein 10; PRKA10; Dual specificity A kinase-anchoring protein 2
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total AKAP10 protein.
  • Applications：  
  • WB
  • Background：  
  • Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase By similarity.

    Wang L., Proc. Natl. Acad. Sci. U.S.A. 98:3220-3225(2001).
    Chatterjee T.K., Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
    The MGC Project Team, Genome Res. 14:2121-2127(2004).



 
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