Product Datasheet  
M3K13 Antibody  
Catalog Number: 33582  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O43283
    NCBI Gene ID: 9175
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human M3K13.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • Mitogen-activated protein kinase kinase kinase 13; EC 2.7.11.25; Mixed lineage kinase; MLK; Leucine zipper-bearing kinase
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total M3K13 protein.
  • Applications：  
  • WB
  • Background：  
  • Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.

    Sakuma H., J. Biol. Chem. 272:28622-28629(1997).
    Schultz S.J., Cell Growth Differ. 4:821-830(1993).
    Ikeda A., FEBS Lett. 488:190-195(2001).



 
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