Product Datasheet  
XRCC4 Antibody  
Catalog Number: 33549  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q13426
    NCBI Gene ID: 7518
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human XRCC4.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • DNA-repair protein XRCC4; X-ray repair cross-complementing protein 4;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total XRCC4 protein.
  • Applications：  
  • WB
  • Background：  
  • Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

    Ling Chen, J. Biol. Chem., Aug 2000; 275: 26196.
    J¨¦r?me Drouet, J. Biol. Chem., Feb 2005; 280: 7060 - 7069.
    Ulf Grawunder, J. Biol. Chem., Sep 1998; 273: 24708.
    Ray Leber, J. Biol. Chem., Jan 1998; 273: 1794.



 
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