Product Datasheet  
Uba2 Antibody  
Catalog Number: 33535  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UBT2
    NCBI Gene ID: 10054
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human Uba2.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • ANTHRACYCLINE-associated resistance ARX; ARX; EC 6.3.2.-; SUMO-1 activating enzyme subunit 2; UBA2
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Uba2 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

    Mark H. L. Lambermon, Mol. Cell. Biol., Jun 2002; 22: 4346 - 4357.
    Kyoung-Seok Ryu, J. Biol. Chem., Sep 2003; 278: 36621 - 36627.
    R. Jrgen Dohmen, J. Biol. Chem., Jul 1995; 270: 18099.
    Yoshiaki Azuma, FASEB J, Jun 2001; 10.1096.



 
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