Product Datasheet  
Topoisomerase II β Antibody  
Catalog Number: 33528  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q02880
    NCBI Gene ID: 7155
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human topoisomerase II β.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • DNA topoisomerase II; beta isozyme; EC 5.99.1.3; TP2B; TOP2B
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total topoisomerase II β protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

    Ren¨¦ M. Linka, Nucleic Acids Res., May 2007; 10.1093.
    John R. Jenkins, Nucleic Acids Res., Nov 1992; 20: 5587 - 5592.
    Kathryn L. Gilroy, Nucleic Acids Res., Mar 2006; 34: 1597 - 1607.
    Sophie Dereuddre, Cancer Res., Oct 1997; 57: 4301 - 4308.



 
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