Product Datasheet  
SENP1 Antibody  
Catalog Number: 33519  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9P0U3
    NCBI Gene ID: 29843
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from N-terminal of human SENP1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • SUMO1; sentrin specific protease 1; EC 3.4.22.-; Sentrin/SUMO-specific protease SENP1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total SENP1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity.

    Taihei Yamaguchi, Mol. Cell. Biol., Jun 2005; 25: 5171 - 5182.
    Jinke Cheng, Mol. Cell. Biol., Jul 2004; 24: 6021 - 6028.
    Molly A. Brewer, AACR Meeting Abstracts, Mar 2004; 2004: 1006.
    Imke M. Veltman, Hum. Mol. Genet., Jul 2005; 14: 1955 - 1963.



 
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