Product Datasheet  
PIAS4 Antibody  
Catalog Number: 33518  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q8N2W9
    NCBI Gene ID: 51588
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human PIAS4.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • PIAS-gamma; PIASG; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total PIAS4 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

    Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456.
    Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 - 25866.
    Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127.
    Yun Zhao, Stem Cells, Apr 2007; 10.1634.



 
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