Product Datasheet  
PIAS3 Antibody  
Catalog Number: 33517  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9Y6X2
    NCBI Gene ID: 10401
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human PIAS3.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • PROTEIN INHIBITOR OF ACTIVATED STAT3; protein inhibitor of activated STAT 3;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total PIAS3 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.

    Jiang-Hong Man, Nucleic Acids Res., Nov 2006; 34: 5552 - 5566.
    Amir Sonnenblick, Mol. Cell. Biol., Dec 2004; 24: 10584 - 10592.
    Jianyin Long, PNAS, Jan 2004; 101: 99.
    Hyun Duk Jang, J. Biol. Chem., Jun 2004; 279: 24873 - 24880.



 
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