Product Datasheet  
HAT Antibody  
Catalog Number: 33511  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O14929
    NCBI Gene ID: 8520
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human HAT.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • Western blotting: 1:500~1:3000

  • other_names：  
  • Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit; EC 2.3.1.48; HAT1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total HAT protein.
  • Applications：  
  • WB
  • Background：  

  • Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

    Claudia J. Schroder-Adams, Bulletin of Canadian Petroleum Geology, Sep 1997; 45: 356 - 376.
    Pil-Hoon Park, Am J Physiol Gastrointest Liver Physiol, Dec 2005; 289: G1124 - G1136.
    Claudia J. Schroeder-Adams, Palaios, Aug 1998; 13: 361 - 375.
    L. J. Patric




 
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