Product Datasheet  
FAS Antibody  
Catalog Number: 33510  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P25445
    NCBI Gene ID: 355
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human Fas.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Apo-1; CD95; FasL receptor; TNFRSF6; TNR6
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Fas protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

    Michael J. Pinkoski, Am JPhysiol Gastrointest Liver Physiol, Mar 2000; 278: 354.
    Morgan Jenkins, J. Immunol., Aug 1999; 163: 1195.
    Nicholas Mitsiades, J Natl Cancer Inst, Oct 1999; 91: 1678 - 1684.
    JOS? E. CARDIER, FASEB J, Nov 1999; 13: 1950.




 
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