Product Datasheet  
AOS1 Antibody  
Catalog Number: 33506  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UBE0
    NCBI Gene ID: 10055
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human AOS1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • AOS1; HSPC140; SAE1; SUA1; SUMO-1 activating enzyme E1 N subunit
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total AOS1 protein.
  • Applications：  
  • WB IF
  • Background：  
  • The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

    Yoshiaki Azuma, FASEB J, Jun 2001; 10.1096.
    Walter Makous, Invest. Ophthalmol. Vis. Sci., Sep 2006; 47: 4160 - 4167.
    Hsin-Pei Shih, J. Cell Sci., Mar 2002; 115: 1259.
    Thomas Buschmann, J. Biol. Chem., Oct 2001; 276: 40389 - 40395.



 
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