Product Datasheet  
Prostate Apoptosis Response Protein-4 Antibody  
Catalog Number: 33475  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q96IZ0
    NCBI Gene ID: 5074
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human prostate apoptosis response protein-4.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • PAR4; PRKC apoptosis WT1 regulator protein; PRKC; apoptosis; WT1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total prostate apoptosis response protein-4 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

    Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943 - 4950.
    Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
    Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802 - 11810.
    Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.




 
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