Product Datasheet  
P300/CBP Antibody  
Catalog Number: 33460  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q09472/Q92793
    NCBI Gene ID: 8850
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human P300/CBP.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • CREB-binding protein; CREBBP E1A-associated protein p300; EP300; P300 transcription coactivator homolog;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total P300/CBP protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

    Gerd A. Blobel, J. Leukoc. Biol., Apr 2002; 71: 545.
    Eric Kalkhoven, Hum. Mol. Genet., Feb 2003; 12: 441 - 450.
    Wei-fang Shen, Mol. Cell. Biol., Nov 2001; 21: 7509 - 7522.
    Frederick C. Nucifora, Science, Mar 2001; 291: 2423.




 
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