Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
Y Saijoh, Genes Cells, Feb 1996; 1: 239 - 252.
Christopher L. Shaffer, Drug Metab. Dispos., Apr 2007; 10.1124.
Brian Boer, Nucleic Acids Res., Mar 2007; 35: 1773 - 1786.
E Pikarsky, Mol. Cell. Biol., Feb 1994; 14: 1026 - 1038.