Product Datasheet  
Keratin 18 Antibody  
Catalog Number: 33416  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P05783
    NCBI Gene ID: 3875
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Keratin 18.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • Keratin type I cytoskeletal 18; Cytokeratin-18; CK-18 K18;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Keratin 18 protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

    Thomas M. Magin, J. Cell Biol., Mar 1998; 140: 1441.
    Carlos Caul¨ªn, J. Cell Biol., Sep 1997; 138: 1379.
    J Liao, J. Cell Biol., Dec 1995; 131: 1291.
    Nam-On Ku, J. Clin. Invest., Jan 1997; 99: 19.



 
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