Product Datasheet  
NRG1 isoform-10 Antibody  
Catalog Number: 33404  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q15491
    NCBI Gene ID: 3084
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human NRG1 isoform-10.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Pro-neuregulin-1; membrane-bound isoform; Pro-NRG1; NRG1; GGF
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total NRG1 isoform-10 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

    Xiao-Feng Le, Cancer Res., Jul 2000; 60: 3522 - 3531.
    Samuel D. H. Chan, J. Biol. Chem., Sep 1995; 270: 22608.
    Daniel C. Gamett, J. Biol. Chem., Aug 1995; 270: 19022.
    Mohammed Rahmatullah, Mol. Cell. Biol., Nov 1998; 18: 6245 - 6252.




 
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