Product Datasheet  
Granzyme B Antibody  
Catalog Number: 33394  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P10144
    NCBI Gene ID: 2999
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Granzyme B.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • 3.4.21.79; CCPI; CGL-1; CGL1; CSP-B
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Granzyme B protein.
  • Applications：  
  • WB IHC
  • Background：  
  • This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

    David A. Jans, J. Biol. Chem., Nov 1996; 271: 30781.
    Eugene Estella, Diabetes, Aug 2006; 55: 2212 - 2219.
    Yong Gu, J. Biol. Chem., May 1996; 271: 10816.
    Jiuru Sun, J. Biol. Chem., Nov 1996; 271: 27802.



 
© Signalway Biotechnology All Rights Reserved.