Product Datasheet  
E2F4 Antibody  
Catalog Number: 33361  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q16254
    NCBI Gene ID: 1874/1875
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human E2F4.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • E2F-4; p107/p130-binding protein;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total E2F4 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.

    Kathryn M. Kinross, Blood, Aug 2006; 108: 886 - 895.
    Dawei Wang, Mol. Cell. Biol., May 2000; 20: 3417 - 3424.
    Stephan P. Persengiev, Mol. Cell. Biol., Sep 1999; 19: 6048 - 6056.
    Stefan Gaubatz, Mol. Cell. Biol., Feb 2001; 21: 1384 - 1392.



 
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