Product Datasheet  
DNA Polymerase β Antibody  
Catalog Number: 33357  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P06746
    NCBI Gene ID: 5423
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human DNA Polymerase β.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • DNA polymerase beta; EC 2.7.7.7; EC 4.2.99;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total DNA Polymerase β protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

    Hiroyuki Matsumoto, Plant Cell Physiol., Nov 1981; 22: 1317 - 1324.
    L.K. Karagyozov, Nucleic Acids Res., Jun 1978; 5: 1907 - 1917.
    F Costanzo, J. Virol., Mar 1977; 21: 996 - 1001.
    AJ Faber, Eur. J. Biochem., Nov 1981; 120: 357.



 
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