Product Datasheet  
Cyclin F Antibody  
Catalog Number: 33352  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P41002
    NCBI Gene ID: 899
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Cyclin F.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • FBX1; FBXO1; F-box only protein 1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Cyclin F protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.

    Tsz Kan Fung, J. Biol. Chem., Sep 2002; 277: 35140 - 35149.
    Michael T. Tetzlaff, Mol. Cell. Biol., Mar 2004; 24: 2487 - 2498.
    Cain H. Yam, Mol. Cell. Biol., Jan 1999; 19: 635 - 645.
    Michael T. Tetzlaff, PNAS, Mar 2004; 101: 3338 - 3345.



 
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