Product Datasheet  
CREB-BP Antibody  
Catalog Number: 33346  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q92793
    NCBI Gene ID: 1387
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human CREB-BP.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • CREB-binding protein; CBP CBP/MOZ FUSION GENE;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total CREB-BP protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers.

    Zoi Lygerou, Nucleic Acids Res., Feb 1994; 22: 5332 - 5340.
    Karsten Grote, J. Biol. Chem., Dec 2004; 279: 55675 - 55681.
    Kumi Nagamoto-Combs, J. Biol. Chem., Feb 1997; 272: 6051.
    Stephen J. Elliman, Isaac, J. Biol. Chem., Jan 2006; 281: 16 -19



 
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