Product Datasheet  
Bax Antibody  
Catalog Number: 33327  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q07812
    NCBI Gene ID: 581/581
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Bax.
  • reactivity：  
  • Hu Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Apoptosis regulator BAX; membrane isoform alpha; BAXA; Bcl2-associated X protein;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Bax protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

    Francesca Andriani, J Natl Cancer Inst, Sep 2001; 93: 1314 - 1324.
    H Martinez-Valdez, J. Exp. Med., Mar 1996; 183: 971.
    Joslyn K. Brunelle, J. Biol. Chem., Feb 2004; 279: 4305 - 4312.
    Renren Wen, Mol. Cell. Biol., Jan 2001; 21: 678 - 689.



 
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