Product Datasheet  
GRK2 (Ab-86) Antibody  
Catalog Number: 33301  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P25098
    NCBI Gene ID: 156
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from N-terminal of human ADRBK1.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • ADRBK1; adrenergic; beta; receptor kinase 1; ARBK1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total ADRBK1protein.
  • Applications：  
  • WB
  • Background：  
  • Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

    Benovic J.L., FEBS Lett. 283:122-126(1991).
    Chuang T.T., J. Biol. Chem. 267:6886-6892(1992).
    Penn R.B., J. Biol. Chem. 269:14924-14930(1994).




 
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