Product Datasheet  
FRS2 (Ab-196) Antibody  
Catalog Number: 33254  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q8WU20
    NCBI Gene ID: 10818
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human FRS2 around the phosphorylation site of tyrosine 196 (H-T-Y(p)-V-N).
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • FGFR signalling adaptor; FGFR signalling adaptor SNT-1; SNT-1; SNT2; SUC1-associated neurotrophic factor target
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total FRS2 protein.
  • Applications：  
  • WB
  • Background：  
  • Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

    The MGC Project Team; Genome Res. 14:2121-2127(2004).
    Xu H., J. Biol. Chem. 273:17987-17990(1998).
    Meakin S.O., J. Biol. Chem. 274:9861-9870(1999).



 
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