Product Datasheet  
KNTC2 Antibody  
Catalog Number: 33568  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O14777
    NCBI Gene ID: 10403
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human KNTC2.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • HEC1; HEC; Highly expressed in cancer; rich in leucine heptad repeats; KNTC2
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total KNTC2 protein.
  • Applications：  
  • WB IF
  • Background：  
  • Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.

    Chen Y., Mol. Cell. Biol. 17:6049-6056(1997).
    The MGC Project Team, Genome Res. 14:2121-2127(2004).
    Zheng L., Mol. Cell. Biol. 19:5417-5428(1999).



 
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