Product Datasheet  
AurB/C (Ab-202/175) Antibody  
Catalog Number: 33177  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UQB9
    NCBI Gene ID: 9212/6795
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 202/175 (C-G-T(p)-L-D).
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:3000

  • other_names：  
  • AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total AurB/C protein.
  • Applications：  
  • WB
  • Background：  

  • Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.

    Tseng T.-C., DNA Cell Biol. 17:823-833(1998).
    Bernard M., Genomics 53:406-409(1998).
    Kimura M., J. Biol. Chem. 274:7334-7340(1999)




 
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