Product Datasheet  
PLCG1 (Ab-771) Antibody  
Catalog Number: 33125  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P19174
    NCBI Gene ID: 5335
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A).
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Phospholipase C gamma 1; PLC148; PHOSPHOLIPASE C-148;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total PLCG1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.

    Denis Tvorogov, J. Cell Sci., Feb 2005; 118: 601 - 610.
    Brenda J. Irvin, Mol. Cell. Biol., Dec 2000; 20: 9149 - 9161.
    Benoit Poulin, J. Biol. Chem., Feb 2000; 275: 6411.
    Ichiro Nakamura, J. Cell Biol., Jan 2001; 152: 361.



 
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