Product Datasheet  
p130 Cas (Ab-410) Antibody  
Catalog Number: 33124  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P56945
    NCBI Gene ID: 9564
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human p130 Cas around the phosphorylation site of tyrosine 410 (G-V-T-A-V).
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • BCAR1; Breast cancer anti-estrogen resistance 1; CRK-ASSOCIATED SUBSTRATE; CRKAS;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total p130 Cas protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.

    Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 - 37535.
    Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 - H2863.
    Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 - 9189.
    Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 - 6



 
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