Product Datasheet  
CREB (Ab-129/133) Antibody  
Catalog Number: 33188  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P16220
    NCBI Gene ID: 1385
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human CREB around the phosphorylation site of serine 129 or serine 133(S-R-R-P-S).
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • cAMP responsive element binding protein 1; cAMP-response element binding protein; CREB-1; CREB1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total CREB protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

    Xing J, et al. (1998) Mol Cell Biol 18(4): 1946-55.
    Tan Y, et al.( 1996) EMBO J; 15(17): 4629-42.
    Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385.
    Mayo LD, et al. (2001) Biol Chem; 276(27): 25184-9.
    Lu, H. et al. (1997) Mol. Cell. Biol. 17, 5923-59



 
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