Product Datasheet  
DENND1A antibody  
Catalog Number: 31843  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P09497
    NCBI Protein#: BC039703
  • Form of Antibody：  
  • pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein of human DENND1A
  • reactivity：  
  • Hu
  • appl_detail：  

  • IHC dilution:1:50-1:200
  • other_names：  
  • FAM31A; KIAA1608
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • Applications：  
  • IHC
  • Background：  
  • Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).



 
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