Product Datasheet  
LEPR Antibody  
Catalog Number: 31806  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: P48357
    NCBI Gene ID: 3953
    NCBI mRNA#: NM_002303.5
    NCBI Protein#: NP_002294.2
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20�?1 year
  • Immunogen：  
  • A synthesized peptide derived from human LEPR,corresponding to a region within C-terminal amino acids.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  

  • WB dilution: 1:500-1:2000

    IHC dilution: 1:50 - 1:200

    IF dilution: 1:100-1:500

  • other_names：  
  • CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEP-R; LEPR; LEPR_HUMAN; LEPRD; Leptin receptor; Leptin receptor fatty; Leptin receptor gene related protein; Leptin receptor precursor; Leptin receptor precursor; OB R gene related protein; OB receptor
  • Purification：  
  • Affinity purification
  • Specificity：  
  • Applications：  
  • WB IHC IF
  • Background：  

  • The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).




 
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