Product Datasheet  
AGXT Antibody  
Catalog Number: 31276  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Genbank No.: NP_000021
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 280-294 amino acids of human alanine-glyoxylate aminotransferase
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 43kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000
  • other_names：  
  • Alanine-glyoxylate aminotransferase, AGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total AGXT protein.
  • Applications：  
  • ELISA WB
  • Background：  
  • Serine¡ªpyruvate aminotransferase is an enzyme that in humans is encoded by the AGXT gene. This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1), also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract.



 
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