Product Datasheet  
TERT Antibody  
Catalog Number: 31222  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q09470
    Gene ID:3736
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 1120-1132 amino acids of human telomerase reverse transcriptase
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 120kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:50-1:100

  • other_names：  
  • telomerase reverse transcriptase, TP2, TRT, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total TERT protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  

  • Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.




 
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