Product Datasheet  
GJB6 Antibody  
Catalog Number: 31190  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P34995
    Gene ID:5731
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Synthetic peptide corresponding to a region derived from 230-245 amino acids of Human Gap junction beta-6 protein
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Predicted MW: 30kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:500-1:2000
    Immunohistochemistry: 1:10-1:50
  • other_names：  
  • Gap junction beta-6 protein, ED2, EDH, HED, CX30, DFNA3, DFNA3B, DFNB1B
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total GJB6 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.



 
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