Product Datasheet  
DIABLO Antibody  
Catalog Number: 31125  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P48431
    Gene ID:6657
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 56-239 amino acids of human diablo, IAP-binding mitochondrial protein
  • reactivity：  
  • Hu
  • appl_detail：  
  • Predicted MW: 27kd
    ELISA: 1:2000-1:10000
    Western blotting: 1:1000-1:5000
    Immunohistochemistry: 1:100-1:300
  • other_names：  
  • Diablo, IAP-binding mitochondrial protein, SMAC; SMAC3; DFNA64; DIABLO-S
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total DIABLO protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  
  • This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Four alternatively spliced transcript variants have been described for this gene, with two of them encoding different isoforms and the other two probably not encoding a protein. Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.



 
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