Product Datasheet  
AIFM1 Antibody  
Catalog Number: 31026  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9Y5C1
    Gene ID:27329
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to C terminal 250 amino acids of human apoptosis-inducing factor, mitochondrion-associated, 1
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 67kd
    ELISA: 1:1000-1:2000
    Western blotting: 1:200-1:1000
    Immunohistochemistry: 1:15-1:50

  • other_names：  
  • apoptosis-inducing factor, mitochondrion-associated, 1, AIF, PDCD8, COXPD6
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total AIFM1 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  

  • This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.?




 
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