Product Datasheet  
CASP3 Antibody  
Catalog Number: 31010  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P04637
    Gene ID:7157
  • Form of Antibody：  
  • Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein corresponding to a region derived from 1-269 amino acids of human caspase 3, apoptosis-related cysteine peptidase
  • reactivity：  
  • Hu
  • appl_detail：  

  • Predicted MW: 32kd
    ELISA: 1:1000-1:5000
    Western blotting: 1:200-1:1000
    Immunohistochemistry: 1:15-1:50

  • other_names：  
  • caspase 3, apoptosis-related cysteine peptidase, CPP32, SCA-1, CPP32B
  • Purification：  
  • Specificity：  
  • The antibody detects endogenous level of total CASP3 protein.
  • Applications：  
  • ELISA WB IHC
  • Background：  

  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.




 
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