Product Datasheet  
PARN Polyclonal Antibody  
Catalog Number: 30764  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#:O95453
    NCBI Gene ID:5073
  • Form of Antibody：  
  • Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant fusion protein of human PARN (NP_002573.1).
  • reactivity：  
  • Human
  • appl_detail：  
  • WB 1:500 - 1:2000
    IF 1:50 - 1:100
  • other_names：  
  • PARN; DAN; DKCB6; PFBMFT4; poly(A)-specific ribonuclease
  • Purification：  
  • Affinity purification
  • Specificity：  
  • Applications：  
  • WB,IF
  • Background：  
  • The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.



 
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