NR3C2 Polyclonal Antibody

Catalog Number:

30443

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P08235
NCBI Gene ID:4306

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

A synthetic synthetic peptide of human NR3C2 (NP_001159576.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF