APEX1 Polyclonal Antibody

Catalog Number:

30421

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P27695
NCBI Gene ID:328

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human APEX1 (NP_542380.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF

Background:

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:100
IP 1:50 - 1:200

Datasheet PDF