DBI Polyclonal Antibody

Catalog Number:

30286

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P07108
NCBI Gene ID:1622

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human DBI (NP_001171513.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC,IF

Background:

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

References:

appl_detail:

WB 1:1000 - 1:2000
IHC 1:50 - 1:200
IF 1:50 - 1:200

Datasheet PDF