CENPB Polyclonal Antibody

Catalog Number:

29953

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P07199
NCBI Gene ID:1059

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

A synthetic synthetic peptide of human CENPB (NP_001801.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF