MAP3K3 Polyclonal Antibody

Catalog Number:

29702

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q99759
NCBI Gene ID:4215

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human MAP3K3 (NP_976226.1).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC

Background:

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

References:

appl_detail:

WB 1:500 - 1:2000
IHC 1:100 - 1:200

Datasheet PDF