MAP3K8 Polyclonal Antibody

Catalog Number:

29367

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P41279
NCBI Gene ID:1326

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

A synthetic peptide of human MAP3K8 (NP_005195.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF