DDIT3 / CHOP Polyclonal Antibody

Catalog Number:

27243

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P35638
NCBI Gene ID:1649

Form of Antibody:

Avoid freeze / thaw cycles.|Buffer: PBS with 50% glycerol, pH7.4.

Storage/Stability:

Immunogen:

Recombinant fusion protein of human DDIT3 / CHOP (NP_004074.2).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF