LRRTM3 Antibody

Catalog Number:

25257

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q86VH5
Gene ID:347731

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 18 amino acid peptide near the carboxy terminus of human LRRTM3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of LRRTM3 are known to exist; this antibody will only detect the larger isoform.

Applications:

ELISA WB IHC

Background:

The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Recent evidence suggests that LRRTM3 promotes the processing of amyloid-precursor protein (APP) by the beta-secretase BACE, leading to the proteolytic production of the Abeta42 peptide that is the main component of amyloid plaques. Furthermore, LRRTM3 maps to a region of chromosome 10 linked to both late-onset Alzheimer’s disease (AD) and elevated plasma Abeta42 levels, suggesting that LRRTM3 is a functional and positional candidate gene for AD.

References:

appl_detail:

Datasheet PDF