ZBTB7A Antibody

Catalog Number:

25246

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95365
Gene ID:51341

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide near the amino terminus of human ZBTB7A.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least two isoforms of ZBTB7A are known to exist; this antibody will recognize both isoforms. This antibody is predicted to not cross-react with other ZBTB protein family members.

Applications:

ELISA WB IHC

Background:

The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells.

References:

appl_detail:

Datasheet PDF